Advances in Genetics by M. Demerec (Eds.)

By M. Demerec (Eds.)

This quantity in a sequence on genetics, emphasizes the variety of genetic stories. Articles conceal the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable parts and the dropophila gene zeste.

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HOEOWITZ but the further development of biochemical genetics had to await certain advances in both genetics and biochemistry. Among these were the discovery of the mutagenic action of radiations, the development of the idea of metabolism as a complex system of unit processes, the attack on the chemical nature of enzymes, and the spectacular advances in the field of nutrition. For the purposes of chemical genetics certain microorganisms have been found to offer some advantages over the classic materials, Drosophila and maize.

8. Vital staining with cresyl blue. Metachromatic granules ( m ) shown in black. 9. Lipid globules stained with Sudan I11 and drawn black. 10. Glycogen stained with LK. 11. Smear from a 24-hour culture, fixed with Perenyi and stained with ferric hematoxylin and erythrosin. Nuclear element ( n ) black. 12. Same culture aa Fig. 11, smear fixed with 95% alcohol for 20 hours; Feulgen reaction (hydrolysis 10 min. , staining 3 hours). Positive reaction in a few granules shown in solid black, and diffuse positive reaction in the stippled area.

Wall formation then takes place, delimiting eight ascospores. Another mitotic division occurs within each ascospore before maturity. The haploid chromosome number is seven. Previous estimates had been six to nine for N . crassa (Lindegren and Rumann, 1938) and six for N . tetrasperma (Colson, 1934). 7 times longer than the shortest chromosome. Near the end of the short arm of the second longest chromosome is a nucleolus organizer which develops a nucleolus a t each telophase. Preliminary observations on three translocations were made by McClintock, and on two more by Singleton.

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